Many of the world's piping design systems support the use of ISOGEN to create piping isometric drawings. This can be done in two ways – bundled or enabled.
ISOGEN is bundled with design software and its operation is transparent to the user. End user support is provided by the system vendor, not Alias. Software vendors and the systems that support ISOGEN in this way are:
| Intergraph Corp. | PDS® Smart 3D SmartPlant® Isometrics SmartPlant Spoolgen® |
| Bentley Systems Inc. | PlantSpace AutoPLANT AutoPIPE |
| COADE | CADWorx Caesar II |
| AC Plant Consult Software Development GmbH | ACPlant AC Plant Designer |
| Vertex Systems OY | Vertex Plant Design |
| CEA | Plant 4D |
| PROCAD | 3DSMART |
| ITandFactory GmbH | CADISON |
| Venturis IT GmbH | ISOX |
| UNITEC Informationssysteme GmbH | iso.Edge for Solid Edge iso.Works for SolidWorks |
| CAD Partner GmbH | SMAP 3D Piping Iso |
The plant design system does not include ISOGEN software, but it is capable of creating a file (the Piping Component File or PCF) that defines the pipeline to ISOGEN. This file is processed in the separate, standalone application I-Run, or in certain specialized situations, I-Serve. Arrangements for the supply and support of this software is dependent on the plant design system, as detailed in the notes below:
| Parametric Technology Corp. | Pro/Engineer Piping and Cabling Extension CADDS5 |
| AVEVA | Tribon |
| Dassault Systemes | CATIA |
| SolidWorks Corp. | SolidWorks |
| Siemens PLM Software (Unigraphics) | NX |